Tuesday, September 29, 2009
Tuesday, August 25, 2009
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Thursday, August 20, 2009
Education:
1994 M.D.,
1993 Ph.D., Division of Immunology,
1987 B.A.,
Major: Biochemistry
Professional Experience:
2009-present Research Assistant Professor, The University of North Carolina at Chapel Hill
Gillings School of Global Public Health, Chapel Hill, NC.
2007-2009 Visiting Scholar, The University of North Carolina at Chapel Hill
Gillings School of Global Public Health, Chapel Hill, NC.
2006-2007 Regulatory and Intellectual Property Analyst, General Clinical Research Center. Participated in the organizing, writing and editing of the (now funded) UNC Institutional Clinical and Translational Science Award Application to the NIH.
1998-present Founder and Director, The Kenneth S. Warren Institute, Ossining New York.
Supervise all administrative aspects of the non-profit organization including: corporate legal, technology licensing, operations and facility management and construction, animal care and use committee, financial (bookkeeping, auditing, taxes), human resources and laboratory management, business development, set up spin-out company (warren pharmaceuticals – see below).
1996-present Member Scientist, The Kenneth S. Warren Institute, Ossining, New York.
Directly supervised scientific staff of 4 on discovery research project, coordinated scientific collaboration between 12 scientists at KSWI and 20 scientists at H. Lundbeck. Prepared all paperwork and minutes for quarterly joint development meetings.
2001-2004 Founder and Director, Warren Pharmaceuticals, Inc.,
(warrenpharmaceuticals.com).
2004 Chief Operating Officer, Warren Pharmaceuticals, Inc., Ossining, New York
(1) Supervised biologics manufacturing at contract manufacturer (2) Coordinated company’s biologics regulatory affairs (3) Oversaw QA/QC program development and implementation (4) Contract negotiations (5) Organized weekly management meetings to facilitate intra-corporate communication (8) Point person for all due diligence contacts for possible investors during fundraising efforts.
1995-1996 Staff Investigator, The Picower Institute for Medical Research,
1994-1995 Intern, Department of Surgery, North Shore University Hospital, Manhasset, New York
Honors: 1993, New York State Award for Excellence in Student Research in recognition of outstanding thesis work.
1995, Surgical Intern of the Year, North Shore University Hospital
Medical License: 1996-present, New York
Original Publications:
1. Cerami, C., Frevert, U., Sinnis, P., Takacs, B., Clavijo, P.,
2. Cerami, C., Kwakye-Berko, F., Nussenzweig, V. (1992) Binding of malarial circumsporozoite protein to sulfatides and cholesterol-3-sulfate: dependency on disulfide bond formation between cysteines in region II. Molecular and Biochemical Parasitology 54:1-12.
3. Frevert, U., Sinnis, P., Shreffler, Cerami, C., W., Takacs, B., Nussenzweig, V. (1993) Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes. Journal of Experimental Medicine 177:1287-1298
4. Sinnis, P., Clavijo, P., Fenyo, D., Chaite, B., Cerami, C., Nussenzweig, V. (1994) Structural and functional properties of region II-plus of the malaria circumsporozoite protein. Journal of Experimental Medicine 180:297-306.
5. Cerami, C., Frevert, U., Sinnis, P., Takacs, B., Nussenzweig, V. (1994) Rapid clearance of malaria circumsporozoite protein by hepatocytes. Journal of Experimental Medicine 179:695-701.
6. Cerami, C., Zhang, X., Ulrich, P., Bianchi, M., Tracey, K., Berger, B. (1995) High performance liquid chromatographic method for guanylhydrazone compounds. Journal of Chromatography B 675:71-82.
7. Cerami, C., Founds, H., Nicholl, I., Mitsuhashi, T., Giordano, D., Vanpatten, S., Lee, A., Al-abed, Y., Vlassara, H., Bucala, R., Cerami, A. (1997) Tobacco smoke is a source of toxic reactive glycation products. Proceedings of
8. Brines, M.L., Ghezzi, P., Keenan, S., Agnello, D.,
9. Erbayraktar S., Grasso G., Sfacteria A., Xie QW., Coleman T., Kreilgaard M., Torup L., Sager T., Erbayraktar Z., Gokmen L., Yilmaz O., Ghezzi P., Villa P., Fratelli M., Casagrande S., Leist M., Helboe L., Christensen S., Geist A., OStwegaard Pedersen L., Cerami Hand C., Wuerth JP., Cerami A., Brines M., (2003) Asialoerythropoietin is a non-erythropoietin cytokine with broad neuroprotective activity in vivo, Proceedings of National Academy of Sciences Volume 100(11); 6741-6746.
10. Leist, M., Gehzzi, P., Grasso, G., Bianchi, R., Villa, P., Fratelli, M., Savino, C., Bianchi, M., Nielsen, J., Gerwein, J., Kallunki, P., Larsen, A., Helboe, L., Christensen, S., Pedersen, L., Nielsen, M., Torup, L., Sager, T., Sfacteria, A., Erbayraktar, S., Erbayraktar, Z., Gokemn, N., Yilmaz, O., Cerami Hand, C., Xie, QW., Coleman, T., Cerami, A., Brines, M. (2004) Erythropoietin-derived tissue-protective cytokines that do not bind the classical erythropoietin receptor, Science Jul 9;305(5681):239-42.
11. Brines, M., Grasso, G., Fiordaliso, F., Sfacteria, A., Ghezzi, P., Latini, R., Xie, QW., Smart, J., Su-Rick CJ, Pobre, E., Diaz, D., Gomez, D., Hand, C., Coleman, T., Cerami, A. (2004) Erythropoietin mediates tissue protection through an erythropoietin and common
12. Garin T, Rubinstein A, Grigoriadis N, Nedvetzki S, Abramsky O, Mizrachi-Koll R, Hand C, Naor D, Karussis D. (2007) CD44 variant DNA vaccination with virtual lymph node ameliorates experimental autoimmune encephalomyelitis through the induction of apoptosis. Journal of Neurological Science. Jul 15;258(1-2):17-26.
13. Wallach-Dayan SB , Rubinstein AM, Hand C, Breuer R, Naor D (2008). DNA vaccination with CD44 variant isoform reduces mammary tumor local growth and lung metastasis. Molecular Cancer Therapeutics. Jun;7(6):1615-23.
14. Weiss L., Botero-Anug AM, Hand C, Slavin S, Naor D. (2008) CD44 gene vaccination for insulin-dependent diabetes mellitus in non-obese diabetic mice. Israeli Medical Association Journal. Jan;10(1):20-5.
15. Brines, M., Patel, N.S.A., Villa, P., Brines, C., Mennini, T., De Paola, M., Erbayraktar, Z., Erbayraktar, S., Sepodes, B., Thiemermann, Ghezzi, P., Yamin, M. Hand, C., Xie, QW., Coleman, T., Cerami, A. (2008) Non-erythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proceedings of National Academy of Science, 105(31): 10925-30.
Reviews
Cerami, A., Brines, M., Cerami, C., Ghezzi, P., (2001) Effects of Epoetin Alfa on the Central Nervous System - “Seminars in Oncology” Volume 28(2) Suppl. H pp 65-69.
Cerami, A., Brines, M., Ghezzi, P., Cerami, C., Itri, L., (2002) Neuroprotective properties of Epoetin Alfa. Nephrolology Dialysis, Transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association - Supplemental 1:8-12.
US Patents and Patent Applications
(Each of the items listed below has associated international counterparts)
Cerami, C., Bucala, R., Vlassara, H., Cerami, A. Founds, H.W. Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts US patent # 5,850,840 December 22, 1998
Cerami, A., Cerami, C., Gelber, C., Dove, D., Methods and devices for modulating the Immune Response. Filed 4/1/99, Priority 4/1/98
Brines, M., Cerami, A. Cerami, C. Modulation of excitable tissue function by peripherally administered erythropoietin. Filed: 4/13/00, Priority 4/13/99 (Divisionals: Cerebral ischemia, High dose treatment, transcytosis, neurodegenerative conditions, neuromuscular conditions, enhancement of function)
Cerami A., Cerami C., Ulrich P., Methods for removing nucleophilic toxins from tobacco smoke.
US Patent #6,119,701 September 19, 2000
Gerwien, J., Pedersen, J., Nielsen, J., Kallunki, P., Geist, M., Leist, M., Pederson, L., Bay, K., Brines, M., Cerami, A., Cerami C., Sager, T., Christensen, S. Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection and enhancement of erythropoietin-responsive cells, tissues and organs. Filed: 7/01/03, Priority 7/01/02
Cerami A., Cerami C., Ulrich P., Methods for removing nucleophilic toxins from tobacco smoke. US Patent #6,615,842 September 9, 2003
Brines M., Cerami A., Cerami C., Protection and enhancement of erythropoietin-responsive cells, tissues and organs. US Patent #6,531,121 March 11, 2003
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Tuesday, July 7, 2009
Tuesday, June 16, 2009
Wednesday, February 18, 2009
Theo needs a home
THEO NEEDS A HOME
This is Theo – his name is short for Theodore, which means “Gift of God.” He still acts like a naughty puppy, but is really a neutered 9-10-year-old male Wheaten Terrier. He was adopted at the age of 2 years from a Wheaten Terrier Rescue group because of his incompatibility with small children. He has always had terrible separation anxiety and is fearful of strangers. As a younger dog, he loved to chase cats, deer and boys on skateboards. He is older now, has slowed down a bit and does not get as excitable – he ignores cats and deer most of the time, but can still get worked up over skateboards or other male dogs in his territory.
His present owners have two children who are now at college, so the house he lives in is very quiet. His owners are two professionals who are not at home very much. Theo is lonely, anxious, and unfortunately defecating and urinating in the mudroom (he has a doggie door but sometimes won’t use it) and most recently nipped the finger of one of his owners. They cannot have guests over because Theo barks neurotically when anyone is visiting, and has been known to nip visitors.
The sad part is that Theo is a good dog. He desperately wants to love one owner and to lie at their feet or on the nearest couch. He has many good qualities – he is not interested in walking so does not require long walks; he loves car rides in which he goes to sleep rapidly and does not throw up; he does not sleep on your bed – he likes to greet you but prefers having a couch or dog bed close to your bed. He has a good appetite and will eat anything you offer him without vomiting, bloating or getting diarrhea – he loves sushi (but not pickled ginger), roast chicken, roast vegetables, muffins, sandwiches, Mexican food and pasta. You can feed him what you eat and never worry about buying dog food.
Theo is on 40 mg Prozac per day. He eats it in a slice of American cheese. He is also allergic to many environmental variables such as pollen, grass, dust mites and human beings. His allergies flare up in the spring and fall. He has received desensitization injections and responded well to them.
If you adopt Theo, we will stock you up on Prozac and desensitization shots.
If you are interested in adopting Theo, please call Michael at (914) 261-3091 or email him at yamin@optonline.net .
Alternatively you can call Tom, his veterinarian, at 914-309-9664 or email him at smallpets@tomvet.com
